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  Abstract       Curriculum          Bibliografia 
 
 
 
 
Pietro A. Migliaccio
 
 
  Italian
 
 
The remarkable increase in the number of overweight or obese people in all age groups in the industrialized nations is a concern being confronted at various levels in the public health services with differing methodologies but having, at least apparently, meager success. I say “at least apparently” because we do not know what levels of overweightness and obesity would have been reached if it were not for the institutionalized educational campaigns on feeding, and the growing sensitivity of the public at large. The latter element is due to the actions (even if neither coordinated nor continuative) of the several societies and associations that take an active interest in public health problems, especially those linked to feeding. It is almost a question of  emergency: obesity rates lie between 18 and 20% of the adult population and, according to recent surveys, arrive at 36% in individuals still growing. The problem is all the more serious with the knowledge now that the obese child almost always becomes an obese adult. Also with advancing years and in the very elderly, the proportion of people carrying excess weight is rising with serious repercussions for self-sufficiency, for arthrosis problems or for the onset of conditions such as lipoidoproteinoses, diabetes, cardiovascular disorders, etc. 
Alimentation education seeks to prevent, but is only rarely and with difficulty able to cure, the “obesity disease”, something that among other things cannot be fixed beforehand. Therefore it is the physician-nutritionist who has to solve the problem for each individual affected by malnutrition, whether due to excess or want. Today, unfortunately, most people with nutritional problems follow the “do-it-yourself” approach (as if for a common cold) following the advice and diets published by the weeklies, monthlies and dailies and usually put forward by unqualified people. In fact, since every one of us eats, every one of us, as soon as a little renown has been acquired in the most different fields, even if very distant from the medical sciences, absurdly consider ourselves to have the right or duty to talk about diet, to keep a newspaper column and to respond to the most complicated queries on the nutrition and feeding for various conditions. We thus have presenters, actors, dancers, singers, athletes, beauticians, gym instructors, etc., who pronounce on diets and food regimes, certainly in good faith but without being aware of how much they do not know. In reality, this awareness problem also touches on many physicians who prescribe diets for weight loss that have no scientific foundation, thinking only of the near future results and not the possibility of short or long-term harm. They often prescribe drugs, or more frequently drug cocktails, that they do not know the actions, synergies, antagonisms or summation of (or that are often not scientifically known). To their credit, however, it should be pointed out that they never engage patients in diets for renal failure, diabetes, hyperuricacidemia, diverticulosis or other more or less serious diseased conditions. I would advise all those who go to nutritionists to immediately ask them if they would be disposed to taking care of, and prescribing a diet for, a relation affected by serious chronic renal failure or by celiac disease or ulcerative colitis. If the response is negative, it would be only right to change to a specialist because this is something that probably they are not!  
I mention this because many physicians act as nutritionists or dietitians, sometimes without ever having taken examinations in Nutrition Science. On the other hand, medical unemployment, the ample possibilities for work in the dietetics field, and the apparent ease of the task, convince many to travel this route. A problem therefore arises, that would be dietetic if it only regarded the medics but which really becomes a general ethical concern, given the large number of people outside of medicine who also get themselves involved. If by “ethics” we mean that set of public and private behavior norms that an individual or group follow in the interests of, respect for and well-being of the individual and Society as a whole, then we should talk about the need for ethics in dietetics. It is not moral to prescribe diets or advise feeding regimes if it does not lie within one's province to do so, i.e. if appropriate studies have not been done at university or “para-university” level, such as the courses for dietitians and the current short Degree courses in Nutrition Science. This decidedly rigid position of mine is due to daily observance of the damage caused to the body and psyche of people who follow unbalanced diets or mistaken dietetic formats. Such regimes are usually harmful over a long time, so much  that the subject finds it difficult to make the connection between the previously unbalanced diet and the following disorder.  
I am particularly thinking about anemia, osteoporosis, kidney and gallbladder stones, gastroduodenitis, and the disorders of  thyroid and  other glands with endocrine and exocrine secretions.  
Unfortunately, the advantages of such diets are soon evident, i.e. loss of weight and slimming. But such results do not last long; in fact, the weight is rapidly regained, perhaps with added interest, i.e. a few extra pounds too. But what, then, are the ethics of dietetics?  
In order to address this fundamental question, some things need to be explained. Feeding means coping with an elementary and basic requirement of the organism.  
Nowadays, we understand our bodily needs quite well in this respect and the way to satisfy its demands.  
We eat because it is through the foodstuffs that we introduce what we need to continue living: energy and the nutritive principles (nutrients). 
Energy is necessary for our every bodily activity; the only form of energy that the “human machine” is capable of utilizing is contained in food. A certain quantity is needed, that varies from person to person according to sex, physical dimensions, age and activity level.  
An excessive intake of energy is transformed into fat and is accumulated as such by the body.  
The unit of measurement used to quantify energy was exclusively the “calorie”. This is currently found to be more correctly expressed in “joules” since it is a matter of performed work.  
To transform Calories into Kj, the value in kcal is multiplied by 4.168. In all scientific papers and on nutritional labeling, therefore, the energy values are expressed in Calories and in Joules.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
ALCUNE DELLE DIETE DIMAGRANTI SQUILIBRATE
Dietary Scheme................................Brief Description  ............................Comment 
The Beverly Hills Diet  Fruit only, for 10 days, with gradual addition of other food items but excluding certain food combinations Unbalanced, based on suppositions. Serious side-effects, such as diarrhea, dehydration, shortage of nutritive principles.
The Cambridge Diet Pre-prepared liquid diet with extremely low caloric content (330 calories/day) Dangerously low calorie supply. Leads to serious side-effects that can be harmful to health.
Dr. Atkin'sDiet 
("Diet-points" system)
Poor in carbohydrates and rich in protein. Unbalanced, rich in fats and cholesterol, can cause ketosis and other serious side-effects. Weight-loss is mainly due to loss of water.
Fasting Juices, tea and/or water only. Dangerous, unbalanced, produces only temporary effects.
Diet with human  
chorionic  gondotropin 
(HCG)
A very low calorie diet, with hormone injections. Such injections do not ensure the claimed benefits (in terms of weight-loss).
Fiet based  
on liquid protein
A low-calorie dietetic plan, using pre-packaged preparations. The proteins can be of poor quality. Unbalanced. At best, it may be followed for a short time. Can cause shortages in nutritive principles. 
Mayo Diet A grapefruit to be eaten before meals in order to “burn” the fats. Ineffective, based on a supposition. May only be useful if the No. of calories is reduced. 
Scarsedale Diet Rich in protein. Unbalanced, can provoke ketosis and shortages of nutritive principles.
Dissociated Diet 
"specially balanced  
diet"
Distinguishes two food groups: acid (meat, fish, eggs, cheese, etc.); and alkaline (bread, pasta, rice, legumes, potatoes, etc.); not to be combined in the same meal. Fats, vegetables and spices belonging to a neutral group may be added to the other two.  Unbalanced, can provoke ketosis; may cause iron and calcium deficiencies because of lowered absorption abilities. 
 
Single-food Diet For example, only cheese plus bananas, eggs plus grapefruit, fruit only, etc. Unbalanced and monotonous. At best, to be followed for a short time. Can cause shortages of nutritive principles. 
 
 
Nutritive principles are chemical substances that carry out specific tasks in the organism, assuring its growth, the functioning of all bodily activities and the maintenance of health.  
They comprise: carbohydrates, proteins, fats, vitamins, minerals and water.  
The carbohydrates, proteins and fats are the energy nutrients, i.e. they supply the Calories.  

Precisely:  
1 g. of carbohydrates provide 3.75 kcal;  
1 g. of protein 4 kcal;  
1 g. of fat 9 kcal.  

Alcoholic beverages also supply energy in the quantity of 7 kcal per g. of alcohol. The vitamins, mineral salts and water do not provide energy but are indispensable for the body. The overall daily water requirement may be valued at around 1.5 ml/kcal of the daily energy requirement (e.g. 2,000 ml - 2 liters - for a person having a caloric need of 2,000 kcal). Introduced as drinks, it supplies mineral salts and aids the digestive processes; its daily intake in this form should be about 1.5 liters though this can very much vary depending on environmental conditions, individual characteristics, the kind of physical activities. To obtain the total intake we need to also add what is contained in food and metabolic water. Water is involved in a whole series of functions: it regulates body temperature and cell volume, it is the solvent for all the metabolic reactions, it is essential for transporting the nutrients and for removing the metabolic recrement.  
The various nutrients are to be found in more or less all foods, though in different quantities in one from the other. No single food in itself contains everything in the necessary quantities, so the “complete” food that would satisfy all our nutritional needs does not exist. On the other hand neither does an “irreplaceable” food exist, since each one has certain nutritional properties that can also be found in other food sources.  
Consequently, in order to feed ourselves in a fitting manner, we should learn how to utilize the various foodstuffs we have at our disposal in such a way as to ensure the right nutritive supply that our body needs every day. But to teach individuals or groups how to feed themselves correctly is extremely complicated; to facilitate this task it had been thought, some decades ago, to subdivide foods into seven groups based on their quality, prevailing importance of their supply of nutrients, and their interchangeability. Each group was made up of differing aliments having fairly similar nutritional patterns and it was advised that food selections from each of the seven groups should be represented over the various meals of the day. Recently, in July 1997 to be precise, the “Istituto Nazionale della Nutrizione” put forward a new classification for foods in consideration of the latest research and epidemiological studies. Group 4, which included the legumes, was partly consolidated into Group 1 that comprised meats, fish and eggs, (dry legumes) and partly into Group 5 that was made up of fruit and vegetables, (fresh legumes).  
Further, the components of Groups 6 and 7 were combined. The basic food groups that should find a daily place on the table were therefore reduced to five. I considered it useful to talk of these changes in order to avoid disconcertedness in all those who until now have heard of, or  have spoken about, the seven food groups.  
Let us therefore list the foods that make up the groups, based on the recent modifications suggested by the National Institute of Nutrition:

 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
GROUP 1
The meat, fish and eggs group has the principal function of providing proteins of optimum biological quality, B-complex vitamins, and also oligoelements (especially zinc, copper, and highly bioavailable iron, i.e. easily absorbable and utilizable). As regards eggs, an acceptable consumption for healthy subjects would be one egg 2-3 times a week. From the nutritional point of view, it is convenient to include the dry legumes in this group (beans, chickpeas, peas, lentils, etc.), thus extending the choice and alternative possibilities. This is because these legumes also supply nutrients that are characteristic of meats, fish and eggs, such as iron, other oligoelements and appreciable quantities of good biological quality protein.
 GROUP 2
This is the dairy produce group, which includes milk, yogurt, other dairy products and cheese. The main function of this group is to provide calcium, in a highly bioavailable form. Its components also contain high biological quality protein and some vitamins (particularly B2 and A). Partially skimmed milk and low-fat versions of the dairy products and cheeses should be preferred. 
 
 
GROUP 3
The cereal and tuber group includes: bread, pasta, rice, other minor cereals like maize, oats, barley, spelt, and also potatoes. For Man, these are the most important sources of starch and therefore of energy that is easily utilizable.  
 
 
GROUP 4 
This is the group of condiment fats including those of vegetable origin as well as animal fats. Fat consumption should be limited because they are a concentrated energy source and because an excessive amount in the diet is linked to cardiovascular diseases. However, it should be kept in mind that they do enhance the flavor of food and supply essential fatty acids and the liposoluble vitamins, whose absorption they encourage. Vegetable fats are preferable (especially extra-virgin olive oil) compared to the animal fats (such as butter, cream, lard, bacon fat, etc.). 
GROUP 5
This is the fruit and vegetable group, including fresh legumes, representing very important sources of fiber, provitamin A, vitamin C, other vitamins and the most diverse minerals. It should also be pointed out that there is a significant presence in this group of antioxidants, that carry out an important protective action. 
 
 
 
 
Then there are many types of food  that have not been placed in any of the five groups and that belong to a “personal taste in junk foods” group: made up of candies and desserts, dried fruit, ice cream, sugared drinks, wine, beer, other alcoholic drinks and hard liquor.  
So then, if each of the five groups is represented at least once over the course of consuming the day's meals, the goal of eating in a varied, balanced and complete way will have been achieved, having regard for our economic needs too. Moreover, opportunely inserting food and drinks not to be found in the five groups (desserts, alcohol, ice cream, etc.) we can satisfy our personal tastes even better. So much for the quality of our chosen alimentation. With regard to the quantity of food to be consumed, this is measured, instead, according to various parameters, such as age, sex, size and physical activities. Also to be considered is whether the subject should maintain his/her weight, slim down or put on weight, if the person is still growing or if development is already complete. Pregnancy and breast-feeding periods are two further physiological conditions that pose particular problems for the nutritionist to produce a correct dietary regime, that has to also regard, in the case of a pregnancy, the initial weight and its progress during the term.  
The method that I advise in dietetic therapy consists in prescribing elements from all the groups that should be consumed daily in precise quantities for some of the food items and in approximate quantities for others.  
The diets should always be personalized as much as possible and only prescribed following a careful clinical and feeding history, a medical consultation and a body composition assessment detected with impedance measuring devices or other methods.  
If necessary, the diets are subsequently modified depending on the results obtained and blood tests, if these had not been examined during the first consultation.  
The dietary composition should be as little removed as possible from the percentage proportions held to be ideal among the glucides, proteins and lipids that are 55-65%, 10-12%, less than 30%, respectively, of the overall daily calorie supply.  
Careful attention should also be paid to the distribution of meals over the course of the day.  
 

An example of a diet of around 1,200 kcal, therefore hypocaloric, is the following: 

Breakfast:  210 calories to be assumed from items belonging to all the groups and from outside of the groups but preferably from Groups 2 and 3. 
Example:100 g. partially skimmed milk (1.8% fat) with coffee at will, four Italian-style toasted slices or 30 g. of any kind of cookies or a simple croissant. 

Mid-morning: 100 calories to be taken from all groups and from outside of these. 
Example: An apple or a pear or a small (100 g.) banana or an orange or 200 g. of  pineapple or a squeezed orange juice or a 25 g. packet of crackers or two toasted slices or a 125 g. fruit-containing yogurt (from partially skimmed milk). 
 

Lunch:  One course only: 150 calories from Groups 1-2. 
Example: An 80 g. can of tuna fish in oil, drained, or 60 g. of low-fat cheese or 60 g. of low-fat mozzarella or 80 g. of any kind of cheese (once a week at most) or 60 g. prosciutto crudo (raw ham) with the visible fat removed or cooked ham or  “speck” ham or “bresaola” (dried salted beef) or two eggs (hard-boiled, soft-boiled, poached or scrambled) with tomato, or else something chosen from the foods recommended for dinner. 
Side dish: 50 calories from Group 5. 
Example: All vegetables, including mushrooms and beans; maximum 250 g. raw and net of discarded parts. 
Dressing: 50 calories from Group 4. 
Example: A teaspoon of extra-virgin olive oil. 
Bread: 120 calories from Group 3. 
Example: 40 g. white bread or 50 g. wholemeal bread. 

Afternoon: 100 calories from all of the groups and from outside of them. 
Example: Same as mid-morning, or a cappuccino with one spoonful of sugar or tea with one spoon of sugar and two toasted slices, or a small 20 g. bar of any kind of   chocolate. 

Dinner:  One course only: 150 calories from Groups 1-2. 
Example: 120 g. of veal or young beef or lean beef, or 150 g. chicken-breast or chicken thigh with the upper thigh and without the skin, or 130 g. turkey, or 130 g. lean pork, or 130 g. rabbit meat, or a 100 g. hamburger (120-130 g. if it is stuffed with spinach), or 220-250 g. frozen fish (gross weight) or a 100 g. fillet of white fish or 4/5 fish fingers (cooked in the oven), or else something chosen from the lunch suggestions.  
Vegetables: 50 calories from Group 5. 
Example: Any of the green vegetables, mushrooms and beans; maximum amount 250 g. raw and net of any discarded bits. 
Dressing:  100 calories from Group 4. 
Example: Two teaspoons of extra-virgin olive oil. 
Bread: 120 calories from Group 3. 
Example: 40 g. white bread or 50 g. wholemeal bread.

 
 
 
NEW  
“GUIDELINES FOR HEALTHY ITALIAN EATING” (1997) 
(from “Linee guida per una sana alimentazione italiana”) 
THE SEVEN DIRECTIVES
Control your weight and be active 
An excessive amount of body fat constitutes a health risk, especially for the onset of conditions such as coronary cardiopathy, diabetes, hypertension, some types of cancer, other coronary diseases.  
The greater the weight-load due to fat, the greater the risk. 
Achieving proper body weight is brought about through both a physically more active life and a control on food-intake. 
How much fat, which fats? 
The ideal supply of fats for an adult, to ensure a good state of health, ranges from a minimum of 15% to a maximum of 30% of the overall calorie intake in the diet. For neonates and infants, this amount needs to be higher, up to about 40% of the total calories. The sharing out of these quotas among the different kinds of fatty acids is advised to be the following: saturated, 7-10% of the diet's total calories; monounsaturates, 10-15%; polyunsaturated, 7-10%; all values being approximate.
More cereals, legumes, fruit and vegetables 
In a balanced feeding program, about 60% of the ration's calories should come from carbohydrates, three quarters of which should be chemically complex forms and the remaining quarter as simple carbohydrates. The cereals (and derivatives), legumes, fruit and vegetables, are all good sources of dietary fiber. The recommended amount of fiber is about 30 g. per day,- more than is currently consumed in Italy. 
Sugar, desserts and candies, are O.K.? 
The sugars can be consumed with confidence as sources of glucose (and thus energy) for the body, within the limits of 10-15% of the daily calorie supply. 
Salt? Better not overdo it 
The Italians daily consume much more salt (sodium chloride) than is physiologically necessary. There is an international consensus that suggests an amount not exceeding 6 g. per day, which is equivalent to about 2.4 g. of sodium. 
Alcoholic drinks: if you must, then in moderation 
The daily quantity of alcohol that is considered acceptable corresponds to approximately 0.6 g. per kilogram of body weight.
How to vary and why 
The simplest and surest way to guarantee an adequate supply of all the essential nutrients is to vary your choices as much as possible and to suitably combine these several food items.
 
This is a correct, scientifically balanced diet as far as a hypocaloric diet can be, but which acquires its perfect balance when, in sticking to it, the caloric supply is increased, just as will be specified later on. This is also an optimum distribution of meals throughout the day and for each meal the number of calories is set out, along with the groups from which the food items may be chosen. In this way the person following such a diet has ample choice possibilities. However much it can vary, it will respect (or at least not deviate far from) the ideal amounts of the energy nutrients and should also introduce the right quantities of vitamins and mineral salts. It may also be used as the basis for a “normal calories” diet, increasing the energy supply by adding food elements preferably from Groups 3-4 and with the addition too of wine and some desserts; we shall thus have a balanced, varied and, to a certain degree, personalized diet. For as long as the subject has the will to stick to the prescribed diet, however much the self-management and food choice, it is quite difficult for “the rules” not to be infringed upon. Indeed, hypocaloric diets often have to be followed for long periods of time and so one cannot (indeed should not) avoid some breaches.  
Birthdays, various anniversaries, work dinners or dining with friends, religious feasts, etc., are also opportunities to “backslide” that produce weight-gains and often demoralize the subject and create the excuse to interrupt the hypocaloric slimming dietetic regime.  
To avoid such a drawback, I have put together and proposed a “day after” diet that I have called the “compensation diet”.  
It consists in a day of hypocaloric intake kept within 600-700 calories but which is sufficiently balanced in its smallness.  
Here is how it is made up: 

Breakfast:100 g. partially skimmed milk (1.8% fat) with coffee at will, one toasted slice. 
Lunch: 
One course only: one 80 g. can of tuna in olive oil, drained. 
Side-dish: 250 g. tomatoes or beans. 
Bread: 40 g. white bread or 50 g. wholemeal bread. 
Afternoon:An apple. 
Dinner:One course only: 100 g. chicken breast or a 100 g. hamburger. 
Side-dish: 250 g. of mixed green salad. 
Dressing: one teaspoon of extra-virgin olive oil. 
Bread: 40 g. white or 50 g. wholemeal. 

   (750 kcal)

Stuck to for an entire day, I describe this as “external” compensation. Provision is also made for an “internal” compensation, i.e. to be followed within the same “exception” day, and may be according to this scheme: 

Breakfast:100 g. partially skimmed (1.8%) milk with coffee at will and one toasted slice 
One of the two main meals  
One course only: one 80 g. can of tuna fish in oil, drained. 
Side-dish: 250 g. tomatoes or beans. 
Bread: 40 g. white or 50 g. wholemeal. 
The other main meal: Enjoy the celebration feast! 

This method either allows the weight to be maintained or limits the gain to a few hundred grams; a weight-loss is rarely obtained but it encourages and allows the patient to avoid feeling “haunted” by a diet that goes on “forever”.  
Making use of such a compensation diet therefore allows for some exceptions, both in the course of a weight-loss dietetic regime and in the case of a normal-weight individual whose only need is to maintain that weight.  
After having followed a weight-loss diet and having achieved the desired weight, the question is posed of how to maintain this,- one of the most complex problems in the therapy of obesity. This is a difficult phase and must be carried out with commitment, application and special attention. In fact, if the feeding habits and life-style did not also undergo some changes during the period of the hypocaloric diet, then all of the previously shed weight will be re-gained within a more or less short time and perhaps with “interest”. The faster the loss of weight, the more easily this happens. Furthermore, it is an eventuality that is found, I would say almost inevitably, if the weight-loss was achieved through more or less fasting, by taking substitute meals and (especially), as already alluded to, by resorting to drugs (amphetamines, anorexants, hormones, diuretics, drug cocktails, etc.). 
The maintenance methodology is based on the presupposition, experimentally tested, that for every 700 kcal below the organism's needs that are introduced, an average of 100 g. of body weight are lost. One could then proceed in the following way: the total weight lost expressed in grams is divided by the number of days involved in the diet and the result is the weight-loss per day. Multiplying this by 7, we will have the daily quantity of introduced calories that was below bodily requirements.  
  
Using the equation: 
700 kcal : 100 g. = X : weight lost per day  
We shall have 
X = 700 x daily weight loss / 100 
Reducing to lowest terms: 
X = 7 x daily weight loss 

Where “X” is the number of calories introduced everyday that is below bodily requirements. 

Adding the result obtained to the kcal value of the previously prescribed diet, we shall get the daily requirement for body weight maintenance. For instance, if someone has slimmed down by 10 Kg. after following a 1,200 kcal diet for 100 days, the weight loss will have been 100 g. per day and that means 700 kcal less than bodily needs will have been ingested each day. 
Therefore, theoretically, adding these calculated 700 kcal to the basic 1,200 kcal of the hypocaloric diet, we have 1,900 kcal which ought to represent the daily requirement. If this calculation is also made on the weight loss over the last month of the diet, we shall have some further information that might be useful for a more correct maintenance prescription.  
I realize that this is a theoretical reckoning in that it presupposes that the weight loss graph is linear and not a hyperbola, as usually occurs in real life: a faster weight-loss at the beginning and then continuously slowing down until remaining at a constant weight level in keeping with the calorie intake.  
But at least there will be a reference point on the basis of which maintenance can be effected, that will cover a period of 30-40 days; for this purpose, food items from the Groups least represented in the personalized hypocaloric diet will be utilized.  
So then, after having achieved the weight considered ideal, usually previously decided on and possibly agreed with the patient, one will proceed in the following way: in the first ten days, the calories in the diet will have to be augmented by a certain quantity, in relation to the pregressive caloric deficit, and utilizing food items from Groups 3 and 4; the calories are subsequently increased in degrees, every ten days, getting them from the other food Groups and then from outside of these Groups too; this process continues until the point of “balancing the energy books”, i.e. input = output. 
It will, however, be necessary to maintain weight checks even after stabilization is achieved (once a month for two years), ideally at the same dietetic studio or public/private center, and full medical check-ups spaced out over time.

 
 
 
Principal drugs  
employed  
in treating obesity 
Substances Used to  
Reduce Calorie inTake: 

Anorectic substances 
a)  with a serotonergic action: 
 fenfluramine 
 d-fenfluramine 
 fluoxetine 
b) with a mimetic sympathetic action: 
 amphetamines 
 phenmetrazine 
 amphepramone 
 phentermine 
 mazindol 

Malabsorption-inducing  
substances 
a)  alpha-glucosidase inhibitors 
 acarbose 
 miglitol 
b)  intestinal lipase inhibitors 
 tetrahydrolipstatine 

Substances Used to Increase Energy Expenditure 
a)  having a ß-adrenergic agonist action 
b)  having a serotonergic action  
d-fenfluramine (?)  

Substances Able to Lower  
Insulin Resistence 
a) Biguanides 
 metformin 
 phenformin 
b) Thiazolidinedions 
 ciliathazone 
 trolithazone 
 

 
 
Without a shadow of doubt, the methodology described is scientifically correct and can theoretically be personalized; but this is not sufficient for being ethical or moral, i.e. efficient and harmless. For the utmost dietary personalization, a psychic, physical and moral identification with the patient by the nutritionist physician is necessary. One will thus be able to obtain a feeding regime that copes with the needs of the determined subject for individual nutrients and therefore give satisfaction and a tasty input, plus biochemicals that can promote the synthesis of neurotransmitters which act at various levels, stimulating the immune system among others, including the genital apparatus and the sex hormones to the point of being indirectly aphrodisiac.  
Some neurotransmitters are known but I think there are many more of them and that future research in the nutrition field will be able to identify them with certainty.  
Only the physician's sensitivity, his/her clinical sense that must go beyond the objective examination, can suggest those food items, their quantities and distribution through the day that will obtain the right responses as regards the biochemistry and then also the psychic and psychological ones too.  
One will thus be able to have the sublimation of scientific knowledge in a medical action: the prescription of an ethical diet. Today it is the doctor-patient relationship that can make the diet “ethical” (in virtue of its extreme personalization); perhaps one day there will be tests that would allow this. So, the ethics of diet and the ethical diet,- as if a diet could have a soul and ways of behaving. But I say this as a nutritionist of the old school, having been a researcher and now engaged for decades in treating individuals, without ever neglecting Society as a whole (when the mass-media give me the opportunity to do so).  
Mine is a theory,- it is an attempt to pass on from the mechanicalization and technicalism, to ideation, thought and religion, because of a total respect for the human person in his/her physical, biological, physiological, psychological, philosophical and religious components.  
 

Pietro A. Migliaccio 
Nutrizionista - Dietologo,  
Specialista in Gastroenterologia  
Libero Docente Sc. Alimentazione 
Università di Roma

 
 
 
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