INTRODUCTION
Acoustic
neuroma patients have been during a time span of more than three
decades the subjects of a scientific and clinical debate, as far as the
most suitable surgical access has to be carried out to remove their tumor.
In
the ongoing process to decide whether preoperative hearing should be sacrificed
or not, several hearing functions, in terms of tonal audiograms, discrimination
of words or phrases and in addition the issue of tumor dimensions, did
constitute arguments in favour of an hearing preservation surgery or not.
FUNCTIONAL APPROACHES:
conservative
surgery may be performed, purely depending upon the size of tumor,either
via a “middle cranial fossa approach ”( 1 - 8) or a” suboccipital
approach ”( 9 - 16 ).
The
middle fossa route or the variant called “enlarged middle fossa” is limited,
for reasons of space availability, to tumors confined within the internal
auditory canal or those who have grown into the angle for a few millimeters,
without impinging on neural structures or major vessels.
The
suboccipital and the newest retrosigmoid transmeatal lateral approach
(R.S.T.M.L.), on the other hand, are suitably employed in a wide range
of tumor sizes for tumors of all sizes (9-16; 23-25; 27-31, 33, 36-42).
The
suboccipital approach is best performed for large lesions impinging on
brainstem and posterior fossa vascular structures.
The
retrosigmoid trans meatal lateral approach is preferably carried out in
cases of small or medium sized tumors, not extending in cerebello pontine
angle more than 2 to 2,5 cm.
It
is the surgical access most preferred by the neurosurgical community nowadays.
It
allows full visualization of tumor and cerebello pontine angle, the opening
of internal auditory canal up to the fundus and preservation of cochlear
nerve without even touching inner ear sound-generator structures (26, 32,
34, 35).
To
allow this aim a proper operative patient positioning is required (semisitting;
”amaca”; lateral decubitus position) and graded orientation of the patient
head to easily approach with the drill the internal auditory canal. This
approach is the preferred one in functional surgery for hearing preservation.
DESTRUCTIVE, ABLATIVE
APPROACHES:
translabirinthine
(17- 2O) and trancochlear (21, 22) approaches show
the disadvantage to destroy the hearing supporting structures (Fig.1)
during the operative approach to the tumor,in particular to that part of
the tumor which terminates at or close to the fundus of internal auditory
canal.
These
approaches, in the personal view of the Author, should be reserved to cases
where hearing is not at all present preoperatively or its level is close
to anacusis.
Both
approaches can be used for small or medium sized tumors,with more difficulties
in cases of large space occupying neurinomas.
For
these large neurinomas impinging on neural structures and vessels of the
posterior fossa the enlarged translabyrinthine approach or transcochlear
are better used.
All
the approaches through the temporal bone are tipically of otological interest.
Easiness
to reach the fundus of the canal and to look there for a bony structure(the
Bill's bar), just indicating the presence of the facial nerve at the beginning
of the labyrinthine tract by using the translabyrinthine approach, has
at times renowned interest of the scientific community in this surgical
approach, making cooperation between neurosurgeons and otologists not interested
in the issue of hearing preservation, feasible.
ARGUMENTS IN FAVOUR
OF PRESERVING WHATEVER PREOPERATIVE HEARING
Postoperative
preservation of hearing means integrity, both anatomical and functional,
of cochlear nerve fibers spared by surgery.
Tone
perception treshold not lower than 5OdB and discrimination of speech higher
than 5O% are commomly cosidered as limits posed upon preoperative hearing
function, a key and opening gate leading to functional surgery with respect
to cochlear nerve sparing.
A
wider concept and the availability of sound microneurosurgical skills,
togheter with experienced attitute to save whatever neural function
can be mantained, would induce to try hearing preservation even at the
level of detectable pure tone perception aside from discriminative scores,
which are considered as essential requisite of a useful heraing.
Capacity
to detect pure tones without discrimination of words or phrases does reflect
a neural function at very simple level, but it deserves consideration for
a series of reasons.
Single
detection of discrimination scores,preoperatively determined , is possibly
not representative of the whole patient capability to discriminate and
understand words. Words-phrases and language perception are comprehensive
of many more several aspects of the whole speech processing capability.
Among
these ,discrimination of language in a noisy environment is to be considered,
togheter with sound source localization, the interaction existing between
discrimination capability and lip reading interaction and the effects of
language redundancy.
Moreover,
discrimination scores, when lower than 8O-9O% do show a wide intrinsic
variance: for a given score of 5O% obtained with a 25 words
list, confidence limits of 95% are situated between 28 and 69%, according
to the binomial distribution of discrimination scores.
Therefore
it seems wise to the Author to consider, as the unique prerequisite for
a functional attempt at hearing preservation, the simple preoperative detection
of a pure tone threshold even if not accompanied by satisfactory discrimination
scores.
Whatsoever
preselected audiological criterion, togheter with what is believed to be
its value to pose a candidacy to preservation surgery may lead to
unselection of patients: with regard to preservation of an existing hearing
patrimony, even if at very simple levels, but may possibly exclude some
of them from hearing amelioration after pressure effects of the tumor impinging
on cochlear fibers is taken away.
Hearing
which I also consider worthwhile to be saved is imperfect indeed, but why
destroy it definitely and un-necessarily?
Such
an imperfect hearing may not be useful in verbal perception:
mean level of spoken language is indeed around 6OdB.
On
the other hand that imperfect hearing may become useful in mantaining perception
of an acoustic space all around and for localizing environmental loud stimuli,greatly
exceeding 6O dB.
Low
frequencies of the tonal curve seem particularly worth of preservation,
since well recognized as most relevant in language acquisition process.
INDICATIONS FOR SELECTING
FUNCTIONAL APPROACHES
Theoretically,
dimension of tumor does not constitute predefined limit to preservation
surgery, as already suggested by the Author himself.
Objective
limitations or impossibility to preserve cochlear function can only be
represented by intraoperative findings, direct under the light of the microscope
at high magnification. During surgery, in the case where only part of cochlear
nerve fibers do show a cleavage plan with respect to tumor capsule whereas
others do not,it seems essential at least to try maintenance of this
contingent.
It
is also essential to mantain integrity of vessels directed to the cochlea
(inner ear end organ) and small vessels derived from AICA (anterior inferior
cerebellar artery) supplying nerve bundles themselves.The most proximal
part of the acoustic nerve, called the Root entry zone into the brainstem
is trhe most delicate, since entirely constituted by central myelin.
Cochlear fibers must be cut only if there is intraoperative evidence of
infiltration by tumor tissue.
Only
in that given case where the entire nerve do enter the mass of the tumor,
the wisest thing to do is to cut the nerve in its entirety.
This
case occurring,even an imperfect hearing can not be saved at all.
In the case the tumor is strictly limited to the internal auditory canal,
even in the case where it grows a little bit out of the porus reaching
the angle space,the middle cranial fossa approach (or the enlarged middle
cranial fossa approach) can be carried out (1-8) (Fig.2,3).
In
all other cases,especially when the tumor does reach neural structures
(nerves, cerebellar peduncle, pons or even medulla oblongata) the up to
date approach is the retrosigmoid trasmeatal (25-29, 30-32, 34, 36-42)
(Fig.4,5), preceded by deliquoration of the posterior fossa CSF content
and slight elevation of the cerebellum.
The
opening of the occipital bone is limited to 3-4 cm (Fig.6), the sigmoid
sinus fully exposed,possibly slightly retracted so as to minimize cerebellar
displacement.
Through
this approach, slight cerebellar elevation allows exposure of nerves,vessels
and tumor bulk within the angle (Fig.7,8). Medial surface of petrous pyramid
until the meatal area can be inspected.
Skepticism
regarding the difficulty to total removal of tumor from the inside of
internal autitory canal,is connected to the fact that reaching the
fundus is not an easy task,that appropraite surgical position of the head
has to be mantained,with possibility to vary the visual angle to the deepest
part of the canal (Fig.9).
Surgery
by the retrosigmoid approach can bear the possibility to open ,while drilling
the posterior wall of IAC,the posterior semicircular canal or the vestibule,
thus almost for sure causing loss of function.
Should
such an occasion verify,prompt closure with bony pate' and fibrin glue
or bone wax must be carried out promptly and hearing possibly saved. Inner
ear anatomical preservation and possibility to open the canal from inside
the skull and not coming from the labyrinthine block, therefore the real
possibility to preserve neural function of the cochlear nerve by having
saved the labyrinth, make this approach the preferred one by the vast majority
of neurosurgeons.
The
retrosigmoid approach to the cerebello pontine angle is therefore a functional
way to deal with such tumors, trying to preserve all possible function
of neural structures.
The
step of opening the internal auditory canal is required to debulk the far
lateral extension of the neuroma, which can at times reach the fundus or
even the cochlea, rendering, in this latter case,preservation of any hearing
impossible.
Incision
of the dura, moreover, before beginning the drilling of the posterior canal
wall, should be carried out anterior to the bulging of the saccus endolymphaticus,
so that its integrity is mantained, and hopefully also its function in
draining endolymphatic fluid. Surgical experience shows that opening of
the internal auditory canal is necessary not only in order to preserve
fibers of cochlear nerve exiting the modiulus in the cochlear fossette,
but also to the aim of sparing under direct vision the course and integrity
of the facial nerve.
Facial
nerve in fact may be tightly adherent to the tumor just at the fundus,
where its vascular supply is particularly rich, since it encounters at
this level the vascularity of the labyrinthine portion of the nerve itself.
In the case the the action of blunted dissection cuses traction effects
on the neural structures endangering what we try to save,it is better to
use cutting devices,away from vessels.
Nowaday
knowledge says that no evidence exist that minimal tumor remnants on cochlear
fibers do regrowth in time, thus transforming every our effort in an endlessy
surgical dream, without concrete and realistic result.
In
those patient, very selected indeed, where hearing residuals must be mantained
on the site of operation, it seems wise to leave what is supposed to be
an infiltrated nerve, still functioning (see for example in these cases
the usefulness of intraoperative recordings of Acoustically evoked brainstem
potentials), instead of sacrificing the nerve as a whole, with the expectation
of cochlear or direct brainstem nucei prostheses.
Our
criteria are indeed very broad to select patients, so that the author
trend is to limit the translabirinthine (destructive) approach to whatever
tumor of whatever size, but in which hearing is already lost
or at the end of the tonal scale.
CONCLUSIVE THINKING
ON HEARING PRESERVATION
The
basic concept and the operative phylosophy is to do every possible effort
to save existing neural function at whatever level it may be found preoperatively.
Data
in favour to mantain a simple and defective hearing, defective since it
does not produce any intelligibility of speech, are not at disposal.
On
the other hand nothing has been demonstrated on the issue that better thing
to do is to destroy instead of preserving such a simple and imperfect neural
capability.
It
seems wise to underline that the capability and possibility to convey simple
tones to the brain can and should be tempted, supported by a nerve still
capable to attain tone perception.The author strongly support the opportunity
to mantain both highly qualified as far as simple acoustic function.
The
latter would subserve emergency situations and favour the patient
efficiency in terms of having an”alarm” hearing on one side,subserving
loud stimulation of the auditory pathways.
No
patient operated upon for hearing preservation purposes has never preferred,
postoperatively, not to have that simple hearing still active. It does
not interfere negatively with the really functioning ear.
The
imperfect hearing can be better appreciated in the presence of a not perfectly
functioning ear on the other side.
For
example,an imperfect hearing on the operated side, may allow the placement
of a cochlear implant on the contralateral ear in the case of ensuing anacusis
for whatever reason during life.
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