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Five
tumor cell lines of different origin (glioblastoma, melanoma, kidney
adenocarcinoma, breast carcinoma and lymphoblastic leukemia) were
treated in vitro with the extracts from zebrafish embryos collected
at four different developmental stages. All cell lines responded with
a significant slowing down of the proliferation when treated with
the extracts taken during the stages of cell differentiation, while
no slowing effect was observed when they were treated with the extract
taken from a merely multiplicative stage. These results suggest that
a complex network of molecular factors during embryo differentiation
may help abnormally proliferating cells to normalize their cycle,
and that the administration of embryonic cell differentiation factors
may be a useful tool in cancer therapy. On the other hand, it is known
that the stem cells can be differentiated into different types of
cells in relationship to different kinds of embryonic microenvironment.
Since this network of cell differentiation factors may normalize the
altered expression of genes, we suggest it as a physiological gene
therapy.
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